Endocrine disrupting chemicals (EDCs) are the substances which change the course of endocrine systems in a way that adversely affects the organism itself or its progeny. EDCs call for greater attention because of their increasing utility in daily products and possible correlation with compromised health.It has been reported that PCP is the most important degradation products of phenolic compounds due of its enhanced resistance towards biodegradation. Effect of Pentachlorophenol (PCP) on the histology of Liver of a fresh water Catfish Heteropneustes fossilis was studied by exposing the fish to 32ìg/l/day (1/10 of LC ) of sub lethal 50 concentration of PCPfor a period of 14 and 28 days. Histopathological changes observed in liver was vacuolization, necrosis, rupturing of hepatocytes th th during different time of exposure i.e., 14 and 28 days. In our present study PCP(32ìg/l/day) showed an adverse impact on liver of fresh water Catfish H. fossilis.
Tulsi has been recognized for thousands of years to be one of India’s greatest health promoting herbs. It has benefits for hundreds of conditions with thousands of years of empirical experience and use.To report the alterations inflicted by Ocimum sanctum (Tulsi) in thyroid and parathyroid gland, the histological studies with these glands were done after administration of a dose of 1 g/ kg body weight for 60 days. Follicles and Interfollicular spaces of thyroid gland and spherical chief cells with oval nuclei of parathyroid gland were similar in both experimental and control groups.The Ocimum sanctum leaves seemed to be non toxic on thyroid and parathyroid cells as we did not observe any pathological symptom in the histology of these vital organs. Thyroprotective effect of Ocimum sanctum leaves may be assumed and could be suggested that Ocimum sanctum is safe for use, but studies are needed with further higher doses and duration to complete the safety profile of this plant.
The effect of Melatonin (MEL) and p-chlorophenyl-alanine (PCPA), a β-adrenergic antagonist on immune and reproductive status was studied during reproductively active phase of Indian Passeriformes Finch, Lonchura punctulata. MEL treatment to these birds showed significant increase in the immune parameters such as spleen weight, blastogenic response of splenocytes, total leukocyte count and lymphocyte count, whereas PCPA treatment showed significant decrease in all these immune parameters. On the other hand the treatment of MEL and PCPA together to the birds showed an increase in immune parameters as compared with control group of birds. Histological observations of the spleen substantiate the data of spleen weight analysis as MEL treatment to the bird increased the splenocytes density in spleen, whereas PCPA treatment to the bird showed depletion of splenocytes in spleen. The results of the present study suggest immune-stimulatory and anti-gonadal effect of the neuro-hormone MEL in this avian species.