The Present study was undertaken to evaluate the therapeutic efficiency of curcumin in terms of normalization of altered serum lipid profile in liver rats exposed to lindane. Liindane (30mg/kg bw) exposure significantly (p<0.001) increase the level of cholesterol (CHO), Triglycerides (TG), very low density lipoprotein (VLDL), low density lipoproteins (LDL) and significantly (p<0.001) decreased High density lipoprotein (HDL)as compared to control. Pre, post-treatment, combination with curcumin (100mg/kg bw) ameliorated CHO, TG, VLDL, LDL level after lindane exposure. However, there was no change in HDL level in IV, V, VI as compared to exposed group. All parameters were metabolized after 14 days exposure to lindane except HDL.
Pesticides are common environmental contaminants incorporating in the food chain due to their indiscriminate use and persistence. The Bioaccumulation of lindane (organochlorine pesticide) is a major threat to human health. We are looking for phytochemicals which may enhance its metabolism and excretion. The ameliorating effect of curcumin (Phenolic phytochemical obtained from turmeric) against lindane induced hematoxicity was studied in wistar rats. Lindane (30mg/kg bw) exposure significantly (P<0.001) decreases the level of Hb, RBC, lymphocytes, mixed cells (eosinophils, basophils, monocytes), PCV and ESR, significantly (P<0.001) increases WBC and neutrophils as compared to control. Pre and post-treatment with curcumin (100 mg/kg bw) ameliorated lindane induced hematotoxicity. However, curcumin co-administered with lindane did not show any ameliorating effect. Lindane hematotoxicity persisted after 14 days of metabolism indicating its persistence.