Textile silk dyeing waste is one of the major sources of hazardous pollutants. Untreated textile dye effluents released from various dyeing industries are often associated with several hepatic diseases and damages both functionally and structurally. In the present work an attempt has been made to find out the impacts of long term exposure of untreated silk dye effluent of small scale cottage industry at Bhagalpur on hepatic tissues of Swiss albino mice, (Mus musculus). The mice were treated orally intragastrically and toxicity was observed at different concentration of silk dye effluent i.e. 25%, 50 %, 75 % and 100% in different time response (15m, 30m, 45th and 60th days). The assimilation of dyeing effluent in body system was supported by biochemical variables. The liver section showed progressive damage which increased with the duration of exposure period than increase in effluent concentration. Hepatic histo-pathological study revealed that female mice suffer from severe hepatic injury like hydropic degeneration of hepatocytes, granulation and dense particles. Hyalinisation was major character identified in the peripheral region of hepatocytes. The findings indicated that silk dye effluent cause a marked alteration in hepatic profile and their effect became more risky at higher dose, because it induces retention of water inside hepatocytes result in odema. The present investigation may be a valuable step in the toxicity assessment of silk dye effluent in Swiss albino mice (Mus musculus).