In the present work an attempt has been made to study the effect of few hormones and pharmacological drugs on changes in proximate composition in whole body in a fresh water air breathing murrel, Channa marulius (Ham.). The water, protein, lipid and carbohydrate + ash content of the fish body (50.0±1.5g) of control group of fishes were 74.79±0.19, 16.02±0.32, 3.21±0.11 and 5.98±0.43% respectively. The treatment of Hydrocortisome and Durabolin brought decrease in water content but increase in protein and lipid content as compared to control. While the treatment of L-thyroxine brought an increase in water content but decrease in protein and lipid content. The details have been discussed in this fish.