Present study investigates synergistic and individual effects of Mercuric chloride and Caldan 50SP on histological profile of testes of Channa punctata. Ten fishes were exposed to sub-lethal concentration (1/10th 96hr. LC„ individually and 1/20th in combination (synergistic effect) for 15, 30 and 60 days, respectively, along with a control. Noticeable histopathological changes were observed in the testes. The extent of damage was exposure dependent under the impact of individual toxicants; however, their synergistic effects pronounced more severe damage even when individual toxicants were in lesser concentration and exposure time was also comparatively lesser. These findings are quite suggestive of reproductive impairments.