Studies on the effect of sublethal concentration of Herboclin (weedicide; 0.30 mg/l) and phosalone (an organophosphate pesticide, 20. Omg/I) were made to evaluate the changes in total proteins (wet weight) content in few tissues (namely -Testes, ovary, liver and muscles) in an air breathing murrel fish, Channa gachua (Ham. ). The exposure of fishes to sublethal concentration of both Herboclin and phosalone caused significant decrease in total protein content as compared to control. The effect was more pronounced in phosalone treatment as compared to control. The reason for such changes has been discussed in this paper.