Studies on the effect of L-thyroxine and testosterone propionate on changes in proximate composition (water, protein, lipid, carbohydrate + ash) in liver muscle, brain, kidney and ovary were made in a fresh water air breathing snake headed murrel fish, Channa striatus (Bloch). The treatment of L-thyroxine (T4) and testosterone proprionate (T.P.) brought an increase in water content in liver and kidney but decrease in protein contents in liver, muscle kidney and gonad. The treatment of T4 and T.P. brought slight increase in lipid content of liver, kidney and brain while decrease in lipid content was clearly marked out in gonad. The reason for such changes have been discussed in this paper.