Studies on the effect of ovariodectomy (OD) on changes in few physiological profiles (such as oxygen uptake and heamatological make up) have been made in a snake headed murrel fish, Channa striatus (Bloch). OD brought significant decrease in R.B.C. counts, Hb content, PCV, M. CH. C. and Oxygen consumption as compared to control (Sham operated). The reason for such changes has been discussed in this paper.